Which line do I take to get to...?
'Prendo' — 'PREN-do'. Stress the first syllable. 'Prendo' literally means 'I take'.
The most basic and essential question at any bus stop when you do not know which route number to take.
'Che linea prendo' literally means 'what line do I take'. 'Per andare a' means 'to go to'. This simple construction is the foundation of all Italian public transport navigation.
Quale autobus va a...?
Which bus goes to...?
Slightly more formal; 'quale' is more precise than 'che'.
Come arrivo a...?
How do I get to...?
Open question that allows any answer — bus, metro, walking.
C'è un autobus diretto per...?
Is there a direct bus to...?
Specifies you want no changes.
In Italian cities, bus route numbers are the primary navigation tool. Locals know their city's bus numbers by heart and give directions using them: 'Prendi il 40' is as natural as giving a street name.